node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carA | carB | lwe1855 | lwe1854 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Carbamoyl-phosphate synthase, large subunit. | 0.999 |
carA | pyrB | lwe1855 | lwe1857 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carA | pyrC | lwe1855 | lwe1856 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
carA | pyrD | lwe1855 | lwe1852 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.988 |
carA | pyrDII | lwe1855 | lwe1853 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotate dehydrogenase (electron transfer subunit); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.982 |
carA | pyrE | lwe1855 | lwe1850 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.984 |
carA | pyrF | lwe1855 | lwe1851 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.984 |
carA | pyrP | lwe1855 | lwe1858 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Uracil permease. | 0.947 |
carA | pyrR | lwe1855 | lwe1859 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.849 |
carA | upp | lwe1855 | lwe2487 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.558 |
carB | carA | lwe1854 | lwe1855 | Carbamoyl-phosphate synthase, large subunit. | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | 0.999 |
carB | pyrB | lwe1854 | lwe1857 | Carbamoyl-phosphate synthase, large subunit. | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrC | lwe1854 | lwe1856 | Carbamoyl-phosphate synthase, large subunit. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
carB | pyrD | lwe1854 | lwe1852 | Carbamoyl-phosphate synthase, large subunit. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.991 |
carB | pyrDII | lwe1854 | lwe1853 | Carbamoyl-phosphate synthase, large subunit. | Dihydroorotate dehydrogenase (electron transfer subunit); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.986 |
carB | pyrE | lwe1854 | lwe1850 | Carbamoyl-phosphate synthase, large subunit. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.989 |
carB | pyrF | lwe1854 | lwe1851 | Carbamoyl-phosphate synthase, large subunit. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.989 |
carB | pyrP | lwe1854 | lwe1858 | Carbamoyl-phosphate synthase, large subunit. | Uracil permease. | 0.940 |
carB | pyrR | lwe1854 | lwe1859 | Carbamoyl-phosphate synthase, large subunit. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.933 |
carB | upp | lwe1854 | lwe2487 | Carbamoyl-phosphate synthase, large subunit. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.536 |