node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carB | pyrB | lwe1854 | lwe1857 | Carbamoyl-phosphate synthase, large subunit. | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrC | lwe1854 | lwe1856 | Carbamoyl-phosphate synthase, large subunit. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
carB | pyrE | lwe1854 | lwe1850 | Carbamoyl-phosphate synthase, large subunit. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.989 |
carB | pyrF | lwe1854 | lwe1851 | Carbamoyl-phosphate synthase, large subunit. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.989 |
carB | pyrH | lwe1854 | lwe1328 | Carbamoyl-phosphate synthase, large subunit. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.433 |
carB | pyrP | lwe1854 | lwe1858 | Carbamoyl-phosphate synthase, large subunit. | Uracil permease. | 0.940 |
carB | pyrR | lwe1854 | lwe1859 | Carbamoyl-phosphate synthase, large subunit. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.933 |
carB | upp | lwe1854 | lwe2487 | Carbamoyl-phosphate synthase, large subunit. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.536 |
pdp | pyrR | lwe2013 | lwe1859 | Pyrimidine-nucleoside phosphorylase. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.914 |
pdp | udk | lwe2013 | lwe1510 | Pyrimidine-nucleoside phosphorylase. | Uridine kinase. | 0.927 |
pdp | upp | lwe2013 | lwe2487 | Pyrimidine-nucleoside phosphorylase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.965 |
pyrB | carB | lwe1857 | lwe1854 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Carbamoyl-phosphate synthase, large subunit. | 0.999 |
pyrB | pyrC | lwe1857 | lwe1856 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrB | pyrE | lwe1857 | lwe1850 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.994 |
pyrB | pyrF | lwe1857 | lwe1851 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.994 |
pyrB | pyrH | lwe1857 | lwe1328 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.414 |
pyrB | pyrP | lwe1857 | lwe1858 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil permease. | 0.990 |
pyrB | pyrR | lwe1857 | lwe1859 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.996 |
pyrB | upp | lwe1857 | lwe2487 | Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.642 |
pyrC | carB | lwe1856 | lwe1854 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Carbamoyl-phosphate synthase, large subunit. | 0.999 |