STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ) (265 aa)    
Predicted Functional Partners:
thiD
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Phosphomethylpyrimidine kinase; Identified by match to protein family HMM TIGR00097
  
 0.999
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
 
 0.999
ABK61380.1
Thiazole tautomerase (transcriptional regulator teni); Thiamine-phosphate pyrophosphorylase, putative; Identified by match to protein family HMM PF02581
 
 0.990
thiG
Thiazole biosynthesis protein thig; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
  
  
 0.759
thiC
Thiamine biosynthesis protein thic; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
  
  
 0.683
ribD
Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate
     
 0.678
ribBA
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
  
  
 0.640
thiF
Sulfur carrier protein this adenylyltransferase; Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM TIGR02354
  
  
 0.494
ABK62058.1
HAD-superfamily hydrolase, putative; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509
       0.410
Your Current Organism:
Clostridium novyi NT
NCBI taxonomy Id: 386415
Other names: C. novyi NT, Clostridium novyi str. NT, Clostridium novyi strain NT, Clostridium novyi-NT
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