node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NIS_1408 | NIS_1414 | NIS_1408 | NIS_1414 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Polysaccharide biosynthesis protein. | 0.791 |
NIS_1408 | ftsH | NIS_1408 | NIS_1409 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.794 |
NIS_1408 | hisA | NIS_1408 | NIS_1411 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | 0.792 |
NIS_1408 | hisH | NIS_1408 | NIS_1412 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.792 |
NIS_1414 | NIS_1408 | NIS_1414 | NIS_1408 | Polysaccharide biosynthesis protein. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.791 |
NIS_1414 | ftsH | NIS_1414 | NIS_1409 | Polysaccharide biosynthesis protein. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.775 |
NIS_1414 | hisA | NIS_1414 | NIS_1411 | Polysaccharide biosynthesis protein. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | 0.799 |
NIS_1414 | hisH | NIS_1414 | NIS_1412 | Polysaccharide biosynthesis protein. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.815 |
ftsH | NIS_1408 | NIS_1409 | NIS_1408 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.794 |
ftsH | NIS_1414 | NIS_1409 | NIS_1414 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Polysaccharide biosynthesis protein. | 0.775 |
ftsH | hisA | NIS_1409 | NIS_1411 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | 0.795 |
ftsH | hisH | NIS_1409 | NIS_1412 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.792 |
hisA | NIS_1408 | NIS_1411 | NIS_1408 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.792 |
hisA | NIS_1414 | NIS_1411 | NIS_1414 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Polysaccharide biosynthesis protein. | 0.799 |
hisA | ftsH | NIS_1411 | NIS_1409 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.795 |
hisA | hisB | NIS_1411 | NIS_0777 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | 0.982 |
hisA | hisC | NIS_1411 | NIS_0390 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.949 |
hisA | hisD | NIS_1411 | NIS_0566 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.983 |
hisA | hisF | NIS_1411 | NIS_0059 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.995 |
hisA | hisG | NIS_1411 | NIS_1169 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.975 |