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glyA protein (Sulfurovum sp. NBC371) - STRING interaction network
"glyA" - Serine hydroxymethyltransferase in Sulfurovum sp. NBC371
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (416 aa)    
Predicted Functional Partners:
folD
Bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (281 aa)
   
  0.996
folC
Folylpolyglutamate synthase (388 aa)
 
  0.991
purH
Bifunctional purine biosynthesis protein PurH (EC-2.1.2.3 3.5.4.10) (510 aa)
   
  0.990
metH
5-methyltetrahydrofolate--homocysteine methyltransferase (1169 aa)
   
 
  0.990
SUN_0642
Phosphoserine phosphatase (207 aa)
   
  0.989
SUN_1208
Pyruvate/2-oxoglutarate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase (442 aa)
 
  0.988
SUN_1210
Pyruvate/2-oxoglutarate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase (464 aa)
 
  0.987
SUN_0641
Methylenetetrahydrofolate reductase (305 aa)
   
 
  0.980
rpiB
Ribose-5-phosphate isomerase B (153 aa)
   
      0.968
purN
Phosphoribosylglycinamide formyltransferase (184 aa)
 
 
  0.957
Your Current Organism:
Sulfurovum sp. NBC371
NCBI taxonomy Id: 387093
Other names: S. sp. NBC37-1, Sulfurovum, Sulfurovum Inagaki et al. 2004, Sulfurovum NBC37_1, Sulfurovum sp. NBC37-1, Sulfurovum sp. NBC371
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