Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
TatD family hydrolase (256 aa)
Predicted Functional Partners:
Membrane-bound lytic murein transglycosylase D (365 aa)
Hypothetical protein (261 aa)
DNA-binding/iron metalloprotein/AP endonuclease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction (337 aa)
YrbI family phosphatase (165 aa)
Imidazoleglycerol-phosphate dehydratase (190 aa)
Hypothetical protein (157 aa)
Acetyltransferase (154 aa)
GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation (213 aa)