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purH protein (Sulfurovum sp. NBC371) - STRING interaction network
"purH" - Bifunctional purine biosynthesis protein PurH (EC:2.1.2.3 3.5.4.10) in Sulfurovum sp. NBC371
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purHBifunctional purine biosynthesis protein PurH (EC-2.1.2.3 3.5.4.10) (510 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase (184 aa)
  0.999
purD
Phosphoribosylamine--glycine ligase (422 aa)
  0.999
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (740 aa)
 
 
  0.998
guaB
Inosine 5’-monophosphate dehydrogenase (481 aa)
   
  0.997
SUN_2371
Adenylosuccinate lyase (443 aa)
   
  0.997
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (416 aa)
 
  0.997
purM
Phosphoribosylaminoimidazole synthetase (331 aa)
 
 
  0.996
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (244 aa)
 
 
  0.995
folD
Bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (281 aa)
   
 
  0.991
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (416 aa)
   
  0.990
Your Current Organism:
Sulfurovum sp. NBC371
NCBI taxonomy Id: 387093
Other names: S. sp. NBC37-1, Sulfurovum, Sulfurovum Inagaki et al. 2004, Sulfurovum NBC37_1, Sulfurovum sp. NBC37-1, Sulfurovum sp. NBC371
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