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leuA protein (Sulfurovum sp. NBC371) - STRING interaction network
"leuA" - 2-isopropylmalate synthase in Sulfurovum sp. NBC371
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (518 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (426 aa)
 
  0.999
leuD
3-isopropylmalate dehydratase small subunit (165 aa)
 
 
  0.996
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (355 aa)
 
  0.994
ilvD
Dihydroxy-acid dehydratase (563 aa)
 
 
  0.994
ilvE
Branched-chain amino acid aminotransferase (304 aa)
   
  0.963
ilvI
Acetolactate synthase 3 catalytic subunit (569 aa)
 
 
  0.949
SUN_2140
Acetolactate synthase, large subunit (597 aa)
 
 
  0.927
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (651 aa)
   
 
  0.920
SUN_0967
acetyl-CoA synthetase (583 aa)
   
 
  0.920
SUN_1209
Pyruvate/2-oxoglutarate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase (446 aa)
     
  0.919
Your Current Organism:
Sulfurovum sp. NBC371
NCBI taxonomy Id: 387093
Other names: S. sp. NBC37-1, Sulfurovum, Sulfurovum Inagaki et al. 2004, Sulfurovum NBC37_1, Sulfurovum sp. NBC37-1, Sulfurovum sp. NBC371
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