node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SUN_0354 | hisB | SUN_0354 | SUN_1227 | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | 0.493 |
SUN_0354 | hisC | SUN_0354 | SUN_2056 | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.936 |
SUN_0354 | hisD | SUN_0354 | SUN_1800 | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.929 |
SUN_0354 | hisH | SUN_0354 | SUN_1950 | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.418 |
SUN_0354 | hisI | SUN_0354 | SUN_0237 | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.759 |
SUN_1362 | SUN_1998 | SUN_1362 | SUN_1998 | Aspartate aminotransferase. | Prephenate dehydrogenase; C terminus of bifunctional TyrA protein, chorismate mutase T EC 5.4.99.5, N-terminal and prephenate dehydrogenase EC 1.3.1.12], C-terminal. | 0.913 |
SUN_1362 | hisC | SUN_1362 | SUN_2056 | Aspartate aminotransferase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.926 |
SUN_1362 | pheA | SUN_1362 | SUN_2057 | Aspartate aminotransferase. | Chorismate mutase/prephenate dehydratase; Bifunctional enzyme. | 0.950 |
SUN_1998 | SUN_1362 | SUN_1998 | SUN_1362 | Prephenate dehydrogenase; C terminus of bifunctional TyrA protein, chorismate mutase T EC 5.4.99.5, N-terminal and prephenate dehydrogenase EC 1.3.1.12], C-terminal. | Aspartate aminotransferase. | 0.913 |
SUN_1998 | hisC | SUN_1998 | SUN_2056 | Prephenate dehydrogenase; C terminus of bifunctional TyrA protein, chorismate mutase T EC 5.4.99.5, N-terminal and prephenate dehydrogenase EC 1.3.1.12], C-terminal. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.981 |
SUN_1998 | pheA | SUN_1998 | SUN_2057 | Prephenate dehydrogenase; C terminus of bifunctional TyrA protein, chorismate mutase T EC 5.4.99.5, N-terminal and prephenate dehydrogenase EC 1.3.1.12], C-terminal. | Chorismate mutase/prephenate dehydratase; Bifunctional enzyme. | 0.972 |
hisB | SUN_0354 | SUN_1227 | SUN_0354 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | 0.493 |
hisB | hisC | SUN_1227 | SUN_2056 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SUN_1227 | SUN_1800 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisB | hisF | SUN_1227 | SUN_2367 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisB | hisG | SUN_1227 | SUN_0424 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.972 |
hisB | hisH | SUN_1227 | SUN_1950 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.997 |
hisB | hisI | SUN_1227 | SUN_0237 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.992 |
hisB | pheA | SUN_1227 | SUN_2057 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Chorismate mutase/prephenate dehydratase; Bifunctional enzyme. | 0.554 |
hisC | SUN_0354 | SUN_2056 | SUN_0354 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol-phosphatase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. | 0.936 |