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nfo protein (Sulfurovum sp. NBC371) - STRING interaction network
"nfo" - Endonuclease IV in Sulfurovum sp. NBC371
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (296 aa)    
Predicted Functional Partners:
SUN_2250
Hypothetical protein (161 aa)
              0.883
polA
DNA polymerase I (898 aa)
     
 
  0.741
SUN_2247
Long-chain fatty acid transport protein (406 aa)
              0.701
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (216 aa)
   
 
  0.645
crr
PTS system, IIA component (156 aa)
         
  0.635
SUN_0010
A/G-specific adenine glycosylase (326 aa)
     
   
  0.624
SUN_2246
long-chain-fatty-acid--CoA ligase (514 aa)
              0.625
SUN_2248
Hypothetical protein (418 aa)
              0.612
nagA
N-acetylglucosamine-6-phosphate deacetylase (374 aa)
              0.604
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...] (732 aa)
   
 
  0.589
Your Current Organism:
Sulfurovum sp. NBC371
NCBI taxonomy Id: 387093
Other names: S. sp. NBC37-1, Sulfurovum, Sulfurovum Inagaki et al. 2004, Sulfurovum NBC37_1, Sulfurovum sp. NBC37-1, Sulfurovum sp. NBC371
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