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hisF protein (Sulfurovum sp. NBC371) - STRING interaction network
"hisF" - Imidazole glycerol phosphate synthase subunit HisF in Sulfurovum sp. NBC371
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (254 aa)    
Predicted Functional Partners:
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (203 aa)
  0.999
hisI
Histidine biosynthesis bifunctional protein HisIE; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family (222 aa)
   
  0.999
hisB
Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal (190 aa)
  0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (430 aa)
 
  0.992
hisA
annotation not available (237 aa)
 
 
0.991
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (206 aa)
 
 
  0.976
hisC
annotation not available (364 aa)
 
  0.961
SUN_2368
annotation not available (176 aa)
   
        0.880
purH
Bifunctional purine biosynthesis protein PurH; Bifunctional enzyme, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (510 aa)
   
 
    0.870
SUN_2371
annotation not available (443 aa)
   
 
    0.826
Your Current Organism:
Sulfurovum sp. NBC371
NCBI taxonomy Id: 387093
Other names: S. sp. NBC37-1, Sulfurovum sp. NBC37-1, Sulfurovum sp. NBC371
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