node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LVIS_0040 | LVIS_0283 | LVIS_0040 | LVIS_0283 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.905 |
LVIS_0040 | LVIS_0576 | LVIS_0040 | LVIS_0576 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
LVIS_0040 | LVIS_1396 | LVIS_0040 | LVIS_1396 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Deoxycytidylate deaminase. | 0.904 |
LVIS_0040 | LVIS_1591 | LVIS_0040 | LVIS_1591 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidine phosphorylase. | 0.904 |
LVIS_0040 | deoD | LVIS_0040 | LVIS_1593 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Purine-nucleoside phosphorylase. | 0.901 |
LVIS_0040 | tdk | LVIS_0040 | LVIS_1291 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.904 |
LVIS_0040 | thyA | LVIS_0040 | LVIS_0784 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.904 |
LVIS_0040 | tmk | LVIS_0040 | LVIS_0604 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.910 |
LVIS_0283 | LVIS_0040 | LVIS_0283 | LVIS_0040 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | 0.905 |
LVIS_0283 | LVIS_1591 | LVIS_0283 | LVIS_1591 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine phosphorylase. | 0.995 |
LVIS_0283 | deoD | LVIS_0283 | LVIS_1593 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Purine-nucleoside phosphorylase. | 0.927 |
LVIS_0283 | tdk | LVIS_0283 | LVIS_1291 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase. | 0.922 |
LVIS_0576 | LVIS_0040 | LVIS_0576 | LVIS_0040 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | 0.900 |
LVIS_0576 | LVIS_1396 | LVIS_0576 | LVIS_1396 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Deoxycytidylate deaminase. | 0.943 |
LVIS_0576 | tdk | LVIS_0576 | LVIS_1291 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.958 |
LVIS_0576 | thyA | LVIS_0576 | LVIS_0784 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.958 |
LVIS_0576 | tmk | LVIS_0576 | LVIS_0604 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.942 |
LVIS_1396 | LVIS_0040 | LVIS_1396 | LVIS_0040 | Deoxycytidylate deaminase. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | 0.904 |
LVIS_1396 | LVIS_0576 | LVIS_1396 | LVIS_0576 | Deoxycytidylate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.943 |
LVIS_1396 | tdk | LVIS_1396 | LVIS_1291 | Deoxycytidylate deaminase. | Thymidine kinase. | 0.928 |