STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NSP1Protein NODULATION SIGNALING PATHWAY 1; Transcriptional regulator essential for Nod-factor-induced gene expression. Acts downstream of calcium spiking. May be a target of DMI3, a calcium/calmodulin- dependent protein kinase (CCaMK). Is essential for Nod factor-elicited expression of ERN1. Transcription factor involved in the control of strigolactone biosynthesis in roots through the activation of the beta-carotene isomerase D27, which participates in a pathway leading to biosynthesis of strigolactones. Belongs to the GRAS family. (554 aa)    
Predicted Functional Partners:
IPD3
Protein CYCLOPS; Involved symbiotic signaling. Required for root infection by symbiotic rhizobia, infection thread (IT) formation, and nodule development. Required for proper induction of early nodulin gene expression. Probably not involved in nodule organogenesis. Involved in arbuscular mycorrhizal (AM) symbiosis. Required for fungal infection of the outer cortical cell layers, and for arbuscule development during the AM symbiosis. Acts downstream of CCAMK. Required for symbiosome formation (i.e. the release of the bacteria from the ITs) and subsequent symbiosome development. Required [...]
  
   
 0.829
CCAMK
Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase DMI-3; During nodulation, plays a central role in bacterial infection and contributes to nodule organogenesis. Protein kinase that recognizes the calcium spiking induced by Nod factors and translates this signal to components controlling nodulation and mycorrhizal infection responses. May phosphorylate the NSP1 protein. Required in epidermal and cortical cells to promote infection thread (IT) formation in root hairs ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
      
 0.778
NFP
Serine/threonine receptor-like kinase NFP; During nodulation, plays a central role in nodule organogenesis. Involved in the perception of Nod factors, the first step of recognition of rhizobia prior to nodulation. Necessary in epidermal cells to induce cortical cell divisions leading to nodule primordia formation. Required during root nodule symbiosis with Sinorhizobium meliloti by triggering infection threads and release of bacteria into the cytoplasm of cells in the infection zone of developing nodules, especially in cells derived from the meristem. Promotes plant fitness (e.g. fruit [...]
      
 0.777
ENOD11
Early nodulin-11; Involved in the infection process during the plant-rhizobium interaction (Probable). Involved in actinorhizal root nodulation. Involved in symbiotic association with the nitrogen-fixing actinomycete Frankia spp (Probable); Belongs to the plant proline-rich protein superfamily.
      
 0.773
ERN2
Ethylene-responsive transcription factor ERN2; Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs). Binds to the GCC box (NF- responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs. Involved in early stages of root nodule development. Functions redundantly with ERN1. Is essential with ERN1 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12. Belo [...]
      
 0.771
RAM2
Glycerol-3-phosphate acyltransferase RAM2; Involved in the production of cutin monomers. Esterifies acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate, a step in cutin biosynthesis (Probable). Required for colonization of the root by mycorrhizal fungi, and appropriate hyphopodia and arbuscule formation. Cutin monomers act as plant signals that promote colonization by arbuscular mycorrhizal fungi. This signaling function has been recruited by pathogenic oomycetes to facilitate appressoria formation and their own invasion.
  
   
 0.750
MtN5
Putative bifunctional inhibitor/plant lipid transfer protein/seed storage helical.
  
   
 0.748
NSP2
Protein NODULATION SIGNALING PATHWAY 2; Transcriptional regulator essential for Nod-factor-induced gene expression. Acts downstream of calcium spiking and DMI3, a calcium/calmodulin-dependent protein kinase (CCaMK). Transcription factor involved in the control of strigolactone biosynthesis in roots through the activation of the beta- carotene isomerase D27, which participates in a pathway leading to biosynthesis of strigolactones. Belongs to the GRAS family.
  
   
0.735
Skl1
EIN2-like protein, nramp transporter.
      
 0.717
Vpy
Putative ankyrin repeat-containing domain-containing protein.
      
 0.690
Your Current Organism:
Medicago truncatula
NCBI taxonomy Id: 3880
Other names: M. truncatula, Medicago truncatula Gaertn., barrel medic
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