STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DMI3Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase DMI-3; During nodulation, plays a central role in bacterial infection and contributes to nodule organogenesis. Protein kinase that recognizes the calcium spiking induced by Nod factors and translates this signal to components controlling nodulation and mycorrhizal infection responses. May phosphorylate the NSP1 protein. Required in epidermal and cortical cells to promote infection thread formation in root hairs; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily (523 aa)    
Predicted Functional Partners:
IPD3
CYCLOPS; Interacting protein of DMI3
   
  
 0.864
DMI1
Ion channel DMI1; Required for early signal transduction events leading to endosymbiosis. Acts early in a signal transduction chain leading from the perception of Nod factor to the activation of calcium spiking. Also involved in mycorrhizal symbiosis. May be involved in the regulation of the calcium channel responsible for calcium spiking by mobilizing another cation, and thereby altering the membrane potential
      
 0.814
NFP
Serine/threonine receptor-like kinase NFP; During nodulation, plays a central role in nodule organogenesis. Involved in the perception of Nod factors, the first step of recognition of rhizobia prior to nodulation. Necessary in epidermal cells to induce cortical cell divisions leading to nodule primordia formation. Required during root nodule symbiosis with Sinorhizobium meliloti by triggering infection threads and release of bacteria into the cytoplasm of cells in the infection zone of developing nodules, especially in cells derived from the meristem. Promotes plant fitness (e.g. fruit [...]
      
 0.808
11444791
EF hand calcium-binding family protein; Calmodulin
    
 
 0.804
11434144
EF hand calcium-binding family protein; Calmodulin
    
 
 0.803
11439466
EF-hand pair protein; Calmodulin
    
 
 0.803
AES75093
Calmodulin
    
 
 0.803
11436534
EF hand calcium-binding family protein; Calmodulin
    
 
 0.803
11425680
Calmodulin
    
 
 0.803
11445057
EF hand calcium-binding family protein; Calmodulin
    
 
 0.803
Your Current Organism:
Medicago truncatula
NCBI taxonomy Id: 3880
Other names: M. truncatula, Medicago truncatula, Medicago truncatula Gaertn., barrel medic
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