STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purBAdenylosuccinate lyase, putative; GC: 51.85%; Codon Adaptation Index (CAI): 0.749. Curator(s): J. Alves; Protein involved in lyase activity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)    
Predicted Functional Partners:
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase, putative; GC: 41.95%; Codon Adaptation Index (CAI): 0.786. Curator(s): J. Alves; Protein involved in purine nucleotide biosynthesis; Belongs to the SAICAR synthetase family.
 0.998
purA
Adenylosuccinate synthetase, putative; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.996
purH
Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves.
  
 0.994
purL
Phosphoribosylformylglycinamidine synthase, putative; GC: 48.7%; Codon Adaptation Index (CAI): 0.782. Curator(s): J. Alves; Protein involved in catalytic activity and ligase activity.
  
  
 0.979
purF
Glutamine phosphoribosylpyrophosphate amidotransferase, putative; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.951
apt
Adenine phosphoribosyltransferase, putative; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.949
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit, putative; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.945
purD
Phosphoribosylamine-glycine ligase; GC: 51.7%; Codon Adaptation Index (CAI): 0.748. Curator(s): J. Alves; Protein involved in ligase activity; Belongs to the GARS family.
  
 
 0.939
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit, putative; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
  
 0.933
adk
Adenylate kinase, putative; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.926
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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