STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase, putative; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (288 aa)    
Predicted Functional Partners:
thrC
Threonine synthase, putative; GC: 48.28%; Codon Adaptation Index (CAI): 0.77. Curator(s): J. Alves; Protein involved in threonine biosynthesis.
 
 0.999
hom
Homoserine dehydrogenase, putative; GC: 43.67%; Codon Adaptation Index (CAI): 0.82. SignalP prediction: Yes (prob. 0.959); Protein involved in amino acid binding and oxidoreductase activity.
 
 0.998
purM
Phosphoribosylformylglycinamidine cyclo-ligase, putative; GC: 47.31%; Codon Adaptation Index (CAI): 0.795. Curator(s): J. Alves.
 
    
 0.907
metB
Cystathionine gamma-synthase, putative; GC: 45.6%; Codon Adaptation Index (CAI): 0.784; Protein involved in amino acid metabolism.
  
 
 0.876
ilvE
Branched-chain amino acid aminotransferase, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.788; Protein involved in transferase activity and branched chain family amino acid metabolism.
  
 
 0.852
cysE
Serine acetyltransferase, putative; GC: 53.72%; Codon Adaptation Index (CAI): 0.747; Protein involved in serine O-acetyltransferase activity and transferase activity.
     
 0.832
sdaB
L-serine dehydratase beta subunit; GC: 41.96%; Codon Adaptation Index (CAI): 0.788; Protein involved in amino acid binding; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.831
sdaA
L-serine dehydratase alpha subunit; GC: 45.7%; Codon Adaptation Index (CAI): 0.81; Protein involved in gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.831
luxS
S-ribosylhomocysteine lyase, putative; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
  
  0.827
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase, putative; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
   
 
 0.820
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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