node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSA_0510 | hisA | SSA_0510 | SSA_1443 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | 0.783 |
SSA_0510 | hisB | SSA_0510 | SSA_1445 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | Imidazole glycerol-phosphate dehydratase, putative; GC: 50.26%; Codon Adaptation Index (CAI): 0.76. | 0.926 |
SSA_0510 | hisD | SSA_0510 | SSA_1446 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | Histidinol dehydrogenase, putative; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.909 |
SSA_0510 | hisE | SSA_0510 | SSA_1440 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | Phosphoribosyl-ATP pyrophosphohydrolase, putative; GC: 51.75%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | 0.739 |
SSA_0510 | hisF | SSA_0510 | SSA_1442 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | Imidazole glycerol-phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.784 |
SSA_0510 | hisG | SSA_0510 | SSA_1447 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.784 |
SSA_0510 | hisH | SSA_0510 | SSA_1444 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | Imidazole glycerol-phosphate synthase subunit hisH, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.815 |
SSA_0510 | hisI | SSA_0510 | SSA_1441 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | Phosphoribosyl-AMP cyclohydrolase, putative; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.810 |
SSA_0510 | hisZ | SSA_0510 | SSA_1448 | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | ATP phosphoribosyltransferase regulatory subunit, putative; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.600 |
hisA | SSA_0510 | SSA_1443 | SSA_0510 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | 0.783 |
hisA | hisB | SSA_1443 | SSA_1445 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Imidazole glycerol-phosphate dehydratase, putative; GC: 50.26%; Codon Adaptation Index (CAI): 0.76. | 0.992 |
hisA | hisC | SSA_1443 | SSA_1449 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase, putative; GC: 49.48%; Codon Adaptation Index (CAI): 0.736; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.904 |
hisA | hisD | SSA_1443 | SSA_1446 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Histidinol dehydrogenase, putative; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
hisA | hisE | SSA_1443 | SSA_1440 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Phosphoribosyl-ATP pyrophosphohydrolase, putative; GC: 51.75%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | 0.982 |
hisA | hisF | SSA_1443 | SSA_1442 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Imidazole glycerol-phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | SSA_1443 | SSA_1447 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.992 |
hisA | hisH | SSA_1443 | SSA_1444 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Imidazole glycerol-phosphate synthase subunit hisH, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SSA_1443 | SSA_1441 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | Phosphoribosyl-AMP cyclohydrolase, putative; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | SSA_1443 | SSA_1448 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; GC: 50.48%; Codon Adaptation Index (CAI): 0.751; Protein involved in isomerase activity. | ATP phosphoribosyltransferase regulatory subunit, putative; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.968 |
hisB | SSA_0510 | SSA_1445 | SSA_0510 | Imidazole glycerol-phosphate dehydratase, putative; GC: 50.26%; Codon Adaptation Index (CAI): 0.76. | L-threonine-O-3-phosphate decarboxylase, putative; GC: 48.58%; Codon Adaptation Index (CAI): 0.77. Curator(s): D. Akan. | 0.926 |