STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
luxSS-ribosylhomocysteine lyase, putative; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (212 aa)    
Predicted Functional Partners:
pfs
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
 
 
 0.990
metB
Cystathionine gamma-synthase, putative; GC: 45.6%; Codon Adaptation Index (CAI): 0.784; Protein involved in amino acid metabolism.
  
 
 0.968
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase, putative; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.965
SSA_0917
Cobalamin-independent methionine synthase II, putative; GC: 48.28%; Codon Adaptation Index (CAI): 0.765. Curator(s): T. Kitten, J. Alves; Protein involved in methionine biosynthesis.
 
  
 0.952
mmuM
Methyltransferase, putative; GC: 43.99%; Codon Adaptation Index (CAI): 0.767. Curator(s): T. Kitten; Protein involved in homocysteine S-methyltransferase activity.
  
  
 0.934
cysK
Cysteine synthase, putative; GC: 47.42%; Codon Adaptation Index (CAI): 0.797; Protein involved in lyase activity and cysteine biosynthesis; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.919
cysD
O-acetylhomoserine sulfhydrylase, putative; GC: 47.07%; Codon Adaptation Index (CAI): 0.799. Curator(s): L. Ozaki; Protein involved in transferase activity, transferring alkyl or aryl (other than methyl) groups and cellodextrin phosphorylase activity.
     
 0.905
SSA_1736
L-cysteine desulfhydrase, putative; GC: 45.5%; Codon Adaptation Index (CAI): 0.794; Protein involved in 1-aminocyclopropane-1-carboxylate synthase activity.
     
  0.900
thrB
Homoserine kinase, putative; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
  
  0.827
hom
Homoserine dehydrogenase, putative; GC: 43.67%; Codon Adaptation Index (CAI): 0.82. SignalP prediction: Yes (prob. 0.959); Protein involved in amino acid binding and oxidoreductase activity.
     
 0.814
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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