STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htrADegP protein, putative; GC: 36.32%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.806. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.974); Protein involved in hydrolase activity. (390 aa)    
Predicted Functional Partners:
ciaR
Two-component system, OmpR family, response regulator CiaR; GC: 40.59%; Codon Adaptation Index (CAI): 0.791. Curator(s): T. Kitten, J. Alves; Protein involved in sensory perception and establishment of competence for transformation.
  
  
 0.943
glpK
Glycerol kinase, putative; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.846
SSA_2382
Chromosome partitioning protein ParB or transcriptional regulator Spo0J, putative; GC: 34.49%; Codon Adaptation Index (CAI): 0.781. Curator(s): J. Alves; Protein involved in plasmid partitioning (sensu Bacteria); Belongs to the ParB family.
     
 0.697
comE
Two-component system transcriptional regulator, LytR/AlgR family, putative; GC: 31.9%; Codon Adaptation Index (CAI): 0.807. Curator(s): J. Alves; Protein involved in sensory perception and regulation of transcription.
  
  
 0.689
comD
Signal transduction protein with a C-terminal ATPase/histidine kinase domain, putative; GC: 31.99%; Transmembrane domains: 7. Codon Adaptation Index (CAI): 0.797. Curator(s): J. Alves; Protein involved in kinase activity and ATP binding.
  
  
 0.688
uncD
Proton-translocating ATPase, F1 sector, beta subunit, putative; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.
   
  
 0.600
leuA
2-isopropylmalate synthase, putative; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
    
 0.596
clpP
ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
  
 0.586
YfkN
Cyclo-nucleotide phosphodiesterase, putative; GC: 48.96%; Codon Adaptation Index (CAI): 0.761. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Curator(s): P. Manque; Protein involved in hydrolase activity, acting on ester bonds.
    
 
 0.577
dnaK
Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.569
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.