node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACA70787.1 | ACA71072.1 | PputW619_0281 | PputW619_0567 | PFAM: aminotransferase class-III; KEGG: pen:PSEEN5296 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.434 |
ACA70787.1 | bioB | PputW619_0281 | PputW619_4840 | PFAM: aminotransferase class-III; KEGG: pen:PSEEN5296 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.626 |
ACA70787.1 | bioD | PputW619_0281 | PputW619_4836 | PFAM: aminotransferase class-III; KEGG: pen:PSEEN5296 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.669 |
ACA70787.1 | bioF | PputW619_0281 | PputW619_4839 | PFAM: aminotransferase class-III; KEGG: pen:PSEEN5296 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.477 |
ACA70787.1 | birA | PputW619_0281 | PputW619_4766 | PFAM: aminotransferase class-III; KEGG: pen:PSEEN5296 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.531 |
ACA71072.1 | ACA70787.1 | PputW619_0567 | PputW619_0281 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: aminotransferase class-III; KEGG: pen:PSEEN5296 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.434 |
ACA71072.1 | bioA | PputW619_0567 | PputW619_0480 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.434 |
ACA71072.1 | bioB | PputW619_0567 | PputW619_4840 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.651 |
ACA71072.1 | bioD | PputW619_0567 | PputW619_4836 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.664 |
ACA71072.1 | bioF | PputW619_0567 | PputW619_4839 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.637 |
ACA71072.1 | birA | PputW619_0567 | PputW619_4766 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.812 |
ACA71072.1 | thiC | PputW619_0567 | PputW619_4714 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.588 |
ACA75314.1 | ACA75317.1 | PputW619_4838 | PputW619_4841 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | KEGG: pen:PSEEN5122 competence protein ComF. | 0.623 |
ACA75314.1 | bioA | PputW619_4838 | PputW619_0480 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.604 |
ACA75314.1 | bioB | PputW619_4838 | PputW619_4840 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.859 |
ACA75314.1 | bioC | PputW619_4838 | PputW619_4837 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.998 |
ACA75314.1 | bioD | PputW619_4838 | PputW619_4836 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.933 |
ACA75314.1 | bioF | PputW619_4838 | PputW619_4839 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.997 |
ACA75317.1 | ACA75314.1 | PputW619_4841 | PputW619_4838 | KEGG: pen:PSEEN5122 competence protein ComF. | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pen:PSEEN5119 biotin biosynthesis BioH. | 0.623 |
ACA75317.1 | bioB | PputW619_4841 | PputW619_4840 | KEGG: pen:PSEEN5122 competence protein ComF. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.641 |