node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
crtE | folD | Ldb1422 | Ldb1425 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.895 |
crtE | nusB | Ldb1422 | Ldb1426 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.789 |
crtE | xseA | Ldb1422 | Ldb1424 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.946 |
crtE | xseB | Ldb1422 | Ldb1423 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.942 |
fhs | fmt | Ldb1020 | Ldb1412 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.465 |
fhs | folD | Ldb1020 | Ldb1425 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | purD | Ldb1020 | Ldb1435 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | ABC transporter, ATP-binding protein (fragment); Putative Cystathionine beta-lyase or Cystathionine gamma-synthase (fragment); Belongs to the GARS family. | 0.640 |
fhs | purH | Ldb1020 | Ldb1436 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Bifunctional enzyme. | 0.981 |
fhs | purN | Ldb1020 | Ldb1437 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.977 |
fhs | thyA | Ldb1020 | Ldb0787 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.439 |
fmt | fhs | Ldb1412 | Ldb1020 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.465 |
fmt | folD | Ldb1412 | Ldb1425 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.978 |
fmt | nusB | Ldb1412 | Ldb1426 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.750 |
fmt | purH | Ldb1412 | Ldb1436 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Bifunctional enzyme. | 0.582 |
fmt | purN | Ldb1412 | Ldb1437 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.950 |
fmt | thyA | Ldb1412 | Ldb0787 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.719 |
folD | crtE | Ldb1425 | Ldb1422 | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.895 |
folD | fhs | Ldb1425 | Ldb1020 | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
folD | fmt | Ldb1425 | Ldb1412 | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.978 |
folD | nusB | Ldb1425 | Ldb1426 | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.937 |