STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)    
Predicted Functional Partners:
Tpet_0178
PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase.
  
 0.984
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.962
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.958
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.955
Tpet_1138
TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain.
  
 
 0.948
Tpet_0587
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
  
 
 0.932
Tpet_1149
TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate transcarbamylase regulatory subunit; aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.
   
  
 0.926
Tpet_1032
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.915
Tpet_1196
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.915
Tpet_1664
TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase.
 
  
 0.913
Your Current Organism:
Thermotoga petrophila
NCBI taxonomy Id: 390874
Other names: T. petrophila RKU-1, Thermotoga petrophila RKU-1, Thermotoga petrophila str. RKU-1, Thermotoga petrophila strain RKU-1, Thermotoga sp. RKU-1
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