STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (397 aa)    
Predicted Functional Partners:
Tpet_1781
PFAM: ExsB family protein; PP-loop domain protein.
 
 0.987
Tpet_1782
NCAIR mutase (PurE)-related protein-like protein.
 
  
 0.980
Tpet_0478
Conserved hypothetical protein.
 
  
 0.743
Tpet_1784
TIGRFAM: oligoendopeptidase, M3 family; PFAM: peptidase M3A and M3B, thimet/oligopeptidase F.
       0.532
Tpet_0889
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
 
    0.481
Tpet_0875
Protein of unknown function DUF362; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF362.
 
     0.426
Tpet_1669
PFAM: ExsB family protein.
  
  
 0.417
Your Current Organism:
Thermotoga petrophila
NCBI taxonomy Id: 390874
Other names: T. petrophila RKU-1, Thermotoga petrophila RKU-1, Thermotoga petrophila str. RKU-1, Thermotoga petrophila strain RKU-1, Thermotoga sp. RKU-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.