node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smal_0048 | Smal_0049 | Smal_0048 | Smal_0049 | KEGG: sfu:Sfum_0326 Sel1 domain protein repeat-containing protein. | PFAM: Sel1 domain protein repeat-containing protein; KEGG: xac:XAC2943 hypothetical protein. | 0.661 |
Smal_0048 | tdk | Smal_0048 | Smal_0047 | KEGG: sfu:Sfum_0326 Sel1 domain protein repeat-containing protein. | PFAM: thymidine kinase; KEGG: xac:XAC4282 thymidine kinase. | 0.779 |
Smal_0049 | Smal_0048 | Smal_0049 | Smal_0048 | PFAM: Sel1 domain protein repeat-containing protein; KEGG: xac:XAC2943 hypothetical protein. | KEGG: sfu:Sfum_0326 Sel1 domain protein repeat-containing protein. | 0.661 |
Smal_0049 | tdk | Smal_0049 | Smal_0047 | PFAM: Sel1 domain protein repeat-containing protein; KEGG: xac:XAC2943 hypothetical protein. | PFAM: thymidine kinase; KEGG: xac:XAC4282 thymidine kinase. | 0.670 |
Smal_0664 | dut | Smal_0664 | Smal_0285 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.430 |
Smal_0664 | tdk | Smal_0664 | Smal_0047 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: thymidine kinase; KEGG: xac:XAC4282 thymidine kinase. | 0.678 |
Smal_0664 | thyA | Smal_0664 | Smal_0662 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
Smal_0664 | tmk | Smal_0664 | Smal_0877 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.410 |
Smal_2603 | dut | Smal_2603 | Smal_0285 | 5'-nucleotidase; PFAM: 5-nucleotidase; KEGG: xac:XAC1596 5'-nucleotidase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
Smal_2603 | surE | Smal_2603 | Smal_1458 | 5'-nucleotidase; PFAM: 5-nucleotidase; KEGG: xac:XAC1596 5'-nucleotidase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Smal_2603 | tdk | Smal_2603 | Smal_0047 | 5'-nucleotidase; PFAM: 5-nucleotidase; KEGG: xac:XAC1596 5'-nucleotidase. | PFAM: thymidine kinase; KEGG: xac:XAC4282 thymidine kinase. | 0.900 |
Smal_2603 | thyA | Smal_2603 | Smal_0662 | 5'-nucleotidase; PFAM: 5-nucleotidase; KEGG: xac:XAC1596 5'-nucleotidase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
Smal_2603 | tmk | Smal_2603 | Smal_0877 | 5'-nucleotidase; PFAM: 5-nucleotidase; KEGG: xac:XAC1596 5'-nucleotidase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
dut | Smal_0664 | Smal_0285 | Smal_0664 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.430 |
dut | Smal_2603 | Smal_0285 | Smal_2603 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 5'-nucleotidase; PFAM: 5-nucleotidase; KEGG: xac:XAC1596 5'-nucleotidase. | 0.900 |
dut | surE | Smal_0285 | Smal_1458 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.913 |
dut | tdk | Smal_0285 | Smal_0047 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | PFAM: thymidine kinase; KEGG: xac:XAC4282 thymidine kinase. | 0.976 |
dut | thyA | Smal_0285 | Smal_0662 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.988 |
dut | tmk | Smal_0285 | Smal_0877 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.977 |
prfA | pyrG | Smal_0721 | Smal_1448 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.729 |