node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smal_1146 | Smal_1924 | Smal_1146 | Smal_1924 | KEGG: xom:XOO_1267 Hsp90xo protein. | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.668 |
Smal_1146 | Smal_3019 | Smal_1146 | Smal_3019 | KEGG: xom:XOO_1267 Hsp90xo protein. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | 0.938 |
Smal_1146 | clpB | Smal_1146 | Smal_3145 | KEGG: xom:XOO_1267 Hsp90xo protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.759 |
Smal_1146 | dnaJ | Smal_1146 | Smal_1601 | KEGG: xom:XOO_1267 Hsp90xo protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.965 |
Smal_1146 | dnaK | Smal_1146 | Smal_1600 | KEGG: xom:XOO_1267 Hsp90xo protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.982 |
Smal_1146 | groL | Smal_1146 | Smal_3626 | KEGG: xom:XOO_1267 Hsp90xo protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.878 |
Smal_1146 | groS | Smal_1146 | Smal_3627 | KEGG: xom:XOO_1267 Hsp90xo protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.795 |
Smal_1146 | grpE | Smal_1146 | Smal_1599 | KEGG: xom:XOO_1267 Hsp90xo protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.719 |
Smal_1924 | Smal_1146 | Smal_1924 | Smal_1146 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | KEGG: xom:XOO_1267 Hsp90xo protein. | 0.668 |
Smal_1924 | Smal_3019 | Smal_1924 | Smal_3019 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | 0.799 |
Smal_1924 | dnaJ | Smal_1924 | Smal_1601 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.793 |
Smal_1924 | dnaK | Smal_1924 | Smal_1600 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
Smal_1924 | groL | Smal_1924 | Smal_3626 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.729 |
Smal_1924 | groS | Smal_1924 | Smal_3627 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.715 |
Smal_1924 | grpE | Smal_1924 | Smal_1599 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.850 |
Smal_1924 | hrcA | Smal_1924 | Smal_1598 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.632 |
Smal_1924 | htpG | Smal_1924 | Smal_1548 | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.668 |
Smal_3019 | Smal_1146 | Smal_3019 | Smal_1146 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | KEGG: xom:XOO_1267 Hsp90xo protein. | 0.938 |
Smal_3019 | Smal_1924 | Smal_3019 | Smal_1924 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | KEGG: xac:XAC2001 ATP-dependent Clp protease subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.799 |
Smal_3019 | clpB | Smal_3019 | Smal_3145 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.799 |