node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smal_1755 | hisA | Smal_1755 | Smal_1761 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: xcb:XC_2376 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.775 |
Smal_1755 | hisB | Smal_1755 | Smal_1759 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | Histidinol-phosphatase; KEGG: xcv:XCV1877 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.830 |
Smal_1755 | hisC | Smal_1755 | Smal_1758 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: xom:XOO_2120 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.715 |
Smal_1755 | hisD | Smal_1755 | Smal_1757 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.771 |
Smal_1755 | hisF | Smal_1755 | Smal_1762 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.789 |
Smal_1755 | hisG | Smal_1755 | Smal_1756 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.798 |
Smal_1755 | hisH | Smal_1755 | Smal_1760 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.790 |
Smal_1755 | hisI | Smal_1755 | Smal_1763 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: xac:XAC1827 hypothetical protein. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: xac:XAC1835 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.859 |
Smal_2584 | hisA | Smal_2584 | Smal_1761 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: xcb:XC_2376 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.943 |
Smal_2584 | hisB | Smal_2584 | Smal_1759 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | Histidinol-phosphatase; KEGG: xcv:XCV1877 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
Smal_2584 | hisC | Smal_2584 | Smal_1758 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: xom:XOO_2120 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.926 |
Smal_2584 | hisD | Smal_2584 | Smal_1757 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.959 |
Smal_2584 | hisF | Smal_2584 | Smal_1762 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.956 |
Smal_2584 | hisG | Smal_2584 | Smal_1756 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.946 |
Smal_2584 | hisH | Smal_2584 | Smal_1760 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.957 |
Smal_2584 | hisI | Smal_2584 | Smal_1763 | PFAM: aminotransferase class I and II; KEGG: xcb:XC_2665 putative aminotransferase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: xac:XAC1835 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.991 |
guaA | hisA | Smal_1672 | Smal_1761 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: xcb:XC_2376 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.800 |
guaA | hisB | Smal_1672 | Smal_1759 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Histidinol-phosphatase; KEGG: xcv:XCV1877 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.554 |
guaA | hisF | Smal_1672 | Smal_1762 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.480 |
guaA | hisH | Smal_1672 | Smal_1760 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.489 |