node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smal_1533 | Smal_2632 | Smal_1533 | Smal_2632 | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | 0.423 |
Smal_1533 | Smal_3520 | Smal_1533 | Smal_3520 | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: xcc:XCC0544 dihydrolipoamide dehydrogenase. | 0.909 |
Smal_1533 | gcvH | Smal_1533 | Smal_3072 | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.989 |
Smal_1533 | gcvP | Smal_1533 | Smal_3000 | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.980 |
Smal_1533 | glyA | Smal_1533 | Smal_0573 | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.637 |
Smal_1533 | purL | Smal_1533 | Smal_0543 | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.429 |
Smal_2632 | Smal_1533 | Smal_2632 | Smal_1533 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | 0.423 |
Smal_2632 | Smal_2655 | Smal_2632 | Smal_2655 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.403 |
Smal_2632 | Smal_3520 | Smal_2632 | Smal_3520 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: xcc:XCC0544 dihydrolipoamide dehydrogenase. | 0.993 |
Smal_2632 | gcvH | Smal_2632 | Smal_3072 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.983 |
Smal_2632 | gcvP | Smal_2632 | Smal_3000 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.948 |
Smal_2632 | gcvT | Smal_2632 | Smal_3073 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.952 |
Smal_2632 | glyA | Smal_2632 | Smal_0573 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
Smal_2655 | Smal_2632 | Smal_2655 | Smal_2632 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | 0.403 |
Smal_2655 | Smal_3520 | Smal_2655 | Smal_3520 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: xcc:XCC0544 dihydrolipoamide dehydrogenase. | 0.637 |
Smal_2655 | gcvP | Smal_2655 | Smal_3000 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.993 |
Smal_2655 | glyA | Smal_2655 | Smal_0573 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.482 |
Smal_3520 | Smal_1533 | Smal_3520 | Smal_1533 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: xcc:XCC0544 dihydrolipoamide dehydrogenase. | TIGRFAM: folate-binding protein YgfZ; PFAM: Glycine cleavage T-protein barrel; KEGG: xom:XOO_2189 hypothetical protein. | 0.909 |
Smal_3520 | Smal_2632 | Smal_3520 | Smal_2632 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: xcc:XCC0544 dihydrolipoamide dehydrogenase. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: xcb:XC_2751 dihydrolipoamide dehydrogenase. | 0.993 |
Smal_3520 | Smal_2655 | Smal_3520 | Smal_2655 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: xcc:XCC0544 dihydrolipoamide dehydrogenase. | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.637 |