node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tmel_0387 | Tmel_0510 | Tmel_0387 | Tmel_0510 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | PFAM: formyl transferase domain protein. | 0.987 |
Tmel_0387 | Tmel_1545 | Tmel_0387 | Tmel_1545 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | IMP cyclohydrolase; PFAM: MGS domain protein. | 0.997 |
Tmel_0387 | fhs | Tmel_0387 | Tmel_0304 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.978 |
Tmel_0387 | folD | Tmel_0387 | Tmel_1907 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.972 |
Tmel_0387 | gcvPB | Tmel_0387 | Tmel_1887 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.485 |
Tmel_0387 | gcvT | Tmel_0387 | Tmel_1885 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
Tmel_0387 | glyA | Tmel_0387 | Tmel_0686 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
Tmel_0387 | purN | Tmel_0387 | Tmel_0388 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
Tmel_0510 | Tmel_0387 | Tmel_0510 | Tmel_0387 | PFAM: formyl transferase domain protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | 0.987 |
Tmel_0510 | Tmel_1545 | Tmel_0510 | Tmel_1545 | PFAM: formyl transferase domain protein. | IMP cyclohydrolase; PFAM: MGS domain protein. | 0.981 |
Tmel_0510 | fhs | Tmel_0510 | Tmel_0304 | PFAM: formyl transferase domain protein. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.952 |
Tmel_0510 | folD | Tmel_0510 | Tmel_1907 | PFAM: formyl transferase domain protein. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
Tmel_0510 | gcvT | Tmel_0510 | Tmel_1885 | PFAM: formyl transferase domain protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.918 |
Tmel_0510 | glyA | Tmel_0510 | Tmel_0686 | PFAM: formyl transferase domain protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
Tmel_0510 | purN | Tmel_0510 | Tmel_0388 | PFAM: formyl transferase domain protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.925 |
Tmel_1545 | Tmel_0387 | Tmel_1545 | Tmel_0387 | IMP cyclohydrolase; PFAM: MGS domain protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region. | 0.997 |
Tmel_1545 | Tmel_0510 | Tmel_1545 | Tmel_0510 | IMP cyclohydrolase; PFAM: MGS domain protein. | PFAM: formyl transferase domain protein. | 0.981 |
Tmel_1545 | fhs | Tmel_1545 | Tmel_0304 | IMP cyclohydrolase; PFAM: MGS domain protein. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.978 |
Tmel_1545 | folD | Tmel_1545 | Tmel_1907 | IMP cyclohydrolase; PFAM: MGS domain protein. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.966 |
Tmel_1545 | gcvPB | Tmel_1545 | Tmel_1887 | IMP cyclohydrolase; PFAM: MGS domain protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.485 |