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purH protein (Burkholderia phymatum) - STRING interaction network
"purH" - KEGG: bte:BTH_I1250 bifunctional purine biosynthesis protein PurH in Burkholderia phymatum
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purHKEGG- bte-BTH_I1250 bifunctional purine biosynthesis protein PurH; TIGRFAM- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- MGS domain protein; AICARFT/IMPCHase bienzyme formylation region (521 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (221 aa)
  0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (448 aa)
 
  0.993
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1359 aa)
 
 
  0.991
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (486 aa)
 
  0.990
purD
Phosphoribosylamine--glycine ligase; KEGG- bxe-Bxe_A3260 phosphoribosylglycinamide synthetase; TIGRFAM- phosphoribosylamine--glycine ligase; PFAM- phosphoribosylglycinamide synthetase; Belongs to the GARS family (425 aa)
 
 
  0.988
Bphy_3303
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (424 aa)
   
  0.984
Bphy_2449
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (415 aa)
   
  0.984
Bphy_2576
TIGRFAM- adenylosuccinate lyase; PFAM- fumarate lyase; Adenylosuccinate lyase domain protein; KEGG- bxe-Bxe_A0593 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (462 aa)
   
  0.984
folD
Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (285 aa)
 
  0.982
purM
KEGG- bxe-Bxe_A3936 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM- phosphoribosylformylglycinamidine cyclo-ligase; PFAM- AIR synthase related protein; AIR synthase related protein domain protein (355 aa)
 
 
  0.978
Your Current Organism:
Burkholderia phymatum
NCBI taxonomy Id: 391038
Other names: B. phymatum STM815, Burkholderia phymatum, Burkholderia phymatum STM815, Burkholderia phymatum str. STM815, Burkholderia phymatum strain STM815, Burkholderia sp. STM815
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