node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP89002.1 | ABP89003.1 | SSU05_0030 | SSU05_0031 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosyl glycinamide transformylase-N. | 0.999 |
ABP89002.1 | ABP91009.1 | SSU05_0030 | SSU05_2043 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.911 |
ABP89002.1 | fhs | SSU05_0030 | SSU05_0690 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.954 |
ABP89002.1 | fmt | SSU05_0030 | SSU05_0425 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.920 |
ABP89002.1 | folD | SSU05_0030 | SSU05_0497 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.945 |
ABP89002.1 | glyA | SSU05_0030 | SSU05_0852 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
ABP89002.1 | purH | SSU05_0030 | SSU05_0032 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.993 |
ABP89003.1 | ABP89002.1 | SSU05_0031 | SSU05_0030 | Phosphoribosyl glycinamide transformylase-N. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 0.999 |
ABP89003.1 | ABP91009.1 | SSU05_0031 | SSU05_2043 | Phosphoribosyl glycinamide transformylase-N. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.911 |
ABP89003.1 | fhs | SSU05_0031 | SSU05_0690 | Phosphoribosyl glycinamide transformylase-N. | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.954 |
ABP89003.1 | fmt | SSU05_0031 | SSU05_0425 | Phosphoribosyl glycinamide transformylase-N. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.920 |
ABP89003.1 | folD | SSU05_0031 | SSU05_0497 | Phosphoribosyl glycinamide transformylase-N. | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
ABP89003.1 | glyA | SSU05_0031 | SSU05_0852 | Phosphoribosyl glycinamide transformylase-N. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
ABP89003.1 | purH | SSU05_0031 | SSU05_0032 | Phosphoribosyl glycinamide transformylase-N. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.995 |
ABP90741.1 | fhs | SSU05_1775 | SSU05_0690 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.751 |
ABP90741.1 | folD | SSU05_1775 | SSU05_0497 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.976 |
ABP90741.1 | glyA | SSU05_1775 | SSU05_0852 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
ABP90741.1 | metK | SSU05_1775 | SSU05_1621 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.889 |
ABP90741.1 | thyA | SSU05_1775 | SSU05_0834 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.930 |
ABP91009.1 | ABP89002.1 | SSU05_2043 | SSU05_0030 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 0.911 |