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folD protein (Pedobacter sp. BAL39) - STRING interaction network
"folD" - Bifunctional protein FolD in Pedobacter sp. BAL39
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (293 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (423 aa)
 
 
  0.980
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (359 aa)
   
 
  0.960
EDM34059.1
Bifunctional purine biosynthesis protein PurH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) (508 aa)
   
  0.943
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (509 aa)
   
   
  0.929
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (959 aa)
   
 
  0.909
EDM37428.1
Phosphoribosylamine--glycine ligase (Phosphoribosylglycinamide synthetase) (GARS); COG0151 Phosphoribosylamine-glycine ligase (405 aa)
 
 
  0.902
EDM35754.1
COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family (412 aa)
 
 
  0.887
EDM34475.1
COG0015 Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (448 aa)
   
 
  0.866
EDM37060.1
COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain (1219 aa)
       
  0.866
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (264 aa)
   
  0.851
Your Current Organism:
Pedobacter sp. BAL39
NCBI taxonomy Id: 391596
Other names: P. sp. BAL39, Pedobacter sp. BAL39
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