STRINGSTRING
PBAL39_13557 protein (Pedobacter sp. BAL39) - STRING interaction network
"PBAL39_13557" - Dihydrofolate reductase in Pedobacter sp. BAL39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PBAL39_13557Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (161 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis (264 aa)
 
  0.999
PBAL39_02237
Riboflavin biosynthesis protein RibD ; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate (332 aa)
         
  0.895
PBAL39_06231
Folylpolyglutamate synthase (412 aa)
   
  0.892
glyA
Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (423 aa)
   
  0.890
fmt
Methionyl-tRNA formyltransferase ; Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (297 aa)
 
 
  0.878
PBAL39_20670
Putative 2-amino-4-hydroxy-6-hydroxymethylpteridine pyrophosphokinase (164 aa)
 
   
  0.866
gcvT
Glycine cleavage system T protein ; The glycine cleavage system catalyzes the degradation of glycine (359 aa)
   
 
  0.857
PBAL39_04658
Methionine synthase (1219 aa)
   
 
  0.855
gcvP
Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (959 aa)
       
  0.855
PBAL39_07145
Bifunctional purine biosynthesis protein PurH (508 aa)
     
    0.853
Your Current Organism:
Pedobacter sp. BAL39
NCBI taxonomy Id: 391596
Other names: P. sp. BAL39, Pedobacter BAL39, Pedobacter sp. BAL39
Server load: low (9%) [HD]