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leuA protein (Sinorhizobium fredii NGR234) - STRING interaction network
"leuA" - 2-isopropylmalate synthase in Sinorhizobium fredii NGR234
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily (569 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (469 aa)
 
  0.992
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily (201 aa)
   
 
  0.961
ilvD1
annotation not available (612 aa)
   
 
  0.959
ilvE
annotation not available (365 aa)
   
  0.940
NGR_c07270
annotation not available (293 aa)
 
  0.922
ilvD2
annotation not available (580 aa)
   
 
  0.921
NGR_c26400
annotation not available (578 aa)
   
 
  0.921
ilvD3
Dihydroxy-acid dehydratase; DAD; Belongs to the IlvD/Edd family (608 aa)
   
 
  0.921
NGR_c04330
annotation not available (574 aa)
   
 
  0.921
ascA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family (649 aa)
   
 
  0.916
Your Current Organism:
Sinorhizobium fredii NGR234
NCBI taxonomy Id: 394
Other names: Ensifer fredii NGR234, Plasmid pNGR234a, Rhizobium sp. (strain NGR234), Rhizobium sp. NGR234, S. fredii NGR234, Sinorhizobium fredii NGR234, Sinorhizobium sp. NGR234
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