node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI64491.1 | ABI66317.1 | Mmar10_0195 | Mmar10_2025 | KEGG: mag:amb2860 hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.917 |
ABI64491.1 | ABI66503.1 | Mmar10_0195 | Mmar10_2211 | KEGG: mag:amb2860 hypothetical protein. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: pfo:Pfl_4394 glycine cleavage system T protein. | 0.915 |
ABI64491.1 | ABI66728.1 | Mmar10_0195 | Mmar10_2436 | KEGG: mag:amb2860 hypothetical protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
ABI64491.1 | ABI66729.1 | Mmar10_0195 | Mmar10_2437 | KEGG: mag:amb2860 hypothetical protein. | Methionine synthase (B12-dependent); PFAM: homocysteine S-methyltransferase; KEGG: rpc:RPC_3735 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.904 |
ABI64491.1 | fhs | Mmar10_0195 | Mmar10_1412 | KEGG: mag:amb2860 hypothetical protein. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.917 |
ABI64491.1 | folD | Mmar10_0195 | Mmar10_0051 | KEGG: mag:amb2860 hypothetical protein. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
ABI64491.1 | glyA | Mmar10_0195 | Mmar10_1537 | KEGG: mag:amb2860 hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
ABI64491.1 | purH | Mmar10_0195 | Mmar10_2928 | KEGG: mag:amb2860 hypothetical protein. | IMP cyclohydrolase; KEGG: sil:SPO3374 bifunctional purine biosynthesis protein PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein. | 0.913 |
ABI64491.1 | purN | Mmar10_0195 | Mmar10_1246 | KEGG: mag:amb2860 hypothetical protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
ABI65304.1 | fhs | Mmar10_1011 | Mmar10_1412 | KEGG: bmb:BruAb1_1204 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.889 |
ABI65304.1 | folD | Mmar10_1011 | Mmar10_0051 | KEGG: bmb:BruAb1_1204 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.892 |
ABI66317.1 | ABI64491.1 | Mmar10_2025 | Mmar10_0195 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: mag:amb2860 hypothetical protein. | 0.917 |
ABI66317.1 | ABI66503.1 | Mmar10_2025 | Mmar10_2211 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: pfo:Pfl_4394 glycine cleavage system T protein. | 0.921 |
ABI66317.1 | ABI66728.1 | Mmar10_2025 | Mmar10_2436 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
ABI66317.1 | ABI66729.1 | Mmar10_2025 | Mmar10_2437 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase (B12-dependent); PFAM: homocysteine S-methyltransferase; KEGG: rpc:RPC_3735 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.915 |
ABI66317.1 | fhs | Mmar10_2025 | Mmar10_1412 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.941 |
ABI66317.1 | folD | Mmar10_2025 | Mmar10_0051 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.417 |
ABI66317.1 | glyA | Mmar10_2025 | Mmar10_1537 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
ABI66317.1 | purH | Mmar10_2025 | Mmar10_2928 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | IMP cyclohydrolase; KEGG: sil:SPO3374 bifunctional purine biosynthesis protein PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein. | 0.920 |
ABI66317.1 | purN | Mmar10_2025 | Mmar10_1246 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |