node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI64486.1 | hisB | Mmar10_0190 | Mmar10_1614 | KEGG: lpp:lpp2358 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. | Histidinol dehydrogenase, Histidinol-phosphatase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. Belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.612 |
ABI64486.1 | hisG | Mmar10_0190 | Mmar10_1615 | KEGG: lpp:lpp2358 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.839 |
ABI64486.1 | hisI | Mmar10_0190 | Mmar10_1610 | KEGG: lpp:lpp2358 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: xoo:XOO2262 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; In the N-terminal section; belongs to the PRA-CH family. | 0.583 |
ABI64486.1 | prs | Mmar10_0190 | Mmar10_0759 | KEGG: lpp:lpp2358 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.919 |
ABI65908.1 | hisA | Mmar10_1616 | Mmar10_1612 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | 0.809 |
ABI65908.1 | hisB | Mmar10_1616 | Mmar10_1614 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | Histidinol dehydrogenase, Histidinol-phosphatase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. Belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.849 |
ABI65908.1 | hisF | Mmar10_1616 | Mmar10_1611 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.837 |
ABI65908.1 | hisG | Mmar10_1616 | Mmar10_1615 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.839 |
ABI65908.1 | hisH | Mmar10_1616 | Mmar10_1613 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.836 |
ABI65908.1 | hisI | Mmar10_1616 | Mmar10_1610 | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: xoo:XOO2262 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; In the N-terminal section; belongs to the PRA-CH family. | 0.876 |
hisA | ABI65908.1 | Mmar10_1612 | Mmar10_1616 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | 0.809 |
hisA | hisB | Mmar10_1612 | Mmar10_1614 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | Histidinol dehydrogenase, Histidinol-phosphatase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. Belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | Mmar10_1612 | Mmar10_2379 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: mlo:mll3536 imidazole acetol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.971 |
hisA | hisF | Mmar10_1612 | Mmar10_1611 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Mmar10_1612 | Mmar10_1615 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.998 |
hisA | hisH | Mmar10_1612 | Mmar10_1613 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Mmar10_1612 | Mmar10_1610 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: xoo:XOO2262 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisS | Mmar10_1612 | Mmar10_0599 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: xcb:XC_2376 phosphoribosylformimino-5-aminoimidazole carboxam. | KEGG: ccr:CC3513 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein. | 0.456 |
hisB | ABI64486.1 | Mmar10_1614 | Mmar10_0190 | Histidinol dehydrogenase, Histidinol-phosphatase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. Belongs to the imidazoleglycerol-phosphate dehydratase family. | KEGG: lpp:lpp2358 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.612 |
hisB | ABI65908.1 | Mmar10_1614 | Mmar10_1616 | Histidinol dehydrogenase, Histidinol-phosphatase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. Belongs to the imidazoleglycerol-phosphate dehydratase family. | TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: chy:CHY_1082 hypothetical protein. | 0.849 |