node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI64340.1 | surE | Mmar10_0044 | Mmar10_1904 | PFAM: phosphoribulokinase/uridine kinase; KEGG: sth:STH1046 uridine kinase; Belongs to the uridine kinase family. | Exopolyphosphatase / 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
ABI64340.1 | tadA | Mmar10_0044 | Mmar10_0619 | PFAM: phosphoribulokinase/uridine kinase; KEGG: sth:STH1046 uridine kinase; Belongs to the uridine kinase family. | tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.570 |
ABI64340.1 | tdk | Mmar10_0044 | Mmar10_2037 | PFAM: phosphoribulokinase/uridine kinase; KEGG: sth:STH1046 uridine kinase; Belongs to the uridine kinase family. | PFAM: thymidine kinase; KEGG: sil:SPO0914 thymidine kinase. | 0.632 |
ABI64487.1 | surE | Mmar10_0191 | Mmar10_1904 | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain; KEGG: pol:Bpro_1194 thymidine phosphorylase. | Exopolyphosphatase / 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.926 |
ABI64487.1 | tdk | Mmar10_0191 | Mmar10_2037 | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain; KEGG: pol:Bpro_1194 thymidine phosphorylase. | PFAM: thymidine kinase; KEGG: sil:SPO0914 thymidine kinase. | 0.938 |
ABI64487.1 | thyA | Mmar10_0191 | Mmar10_2027 | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain; KEGG: pol:Bpro_1194 thymidine phosphorylase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.426 |
dut | surE | Mmar10_3068 | Mmar10_1904 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Exopolyphosphatase / 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.901 |
dut | tdk | Mmar10_3068 | Mmar10_2037 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | PFAM: thymidine kinase; KEGG: sil:SPO0914 thymidine kinase. | 0.973 |
dut | thyA | Mmar10_3068 | Mmar10_2027 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.972 |
dut | tmk | Mmar10_3068 | Mmar10_1454 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.952 |
efp | prfA | Mmar10_2589 | Mmar10_0646 | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.611 |
efp | tdk | Mmar10_2589 | Mmar10_2037 | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | PFAM: thymidine kinase; KEGG: sil:SPO0914 thymidine kinase. | 0.581 |
prfA | efp | Mmar10_0646 | Mmar10_2589 | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | 0.611 |
prfA | pyrG | Mmar10_0646 | Mmar10_1408 | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.698 |
prfA | tdk | Mmar10_0646 | Mmar10_2037 | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | PFAM: thymidine kinase; KEGG: sil:SPO0914 thymidine kinase. | 0.783 |
pyrG | prfA | Mmar10_1408 | Mmar10_0646 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.698 |
pyrG | surE | Mmar10_1408 | Mmar10_1904 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Exopolyphosphatase / 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.454 |
pyrG | tdk | Mmar10_1408 | Mmar10_2037 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | PFAM: thymidine kinase; KEGG: sil:SPO0914 thymidine kinase. | 0.658 |
pyrG | thyA | Mmar10_1408 | Mmar10_2027 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.482 |
surE | ABI64340.1 | Mmar10_1904 | Mmar10_0044 | Exopolyphosphatase / 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | PFAM: phosphoribulokinase/uridine kinase; KEGG: sth:STH1046 uridine kinase; Belongs to the uridine kinase family. | 0.908 |