node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI64298.1 | ABI64692.1 | Mmar10_0002 | Mmar10_0399 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.673 |
ABI64298.1 | ABI65553.1 | Mmar10_0002 | Mmar10_1261 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: ccr:CC1889 ribonucleotide reductase-related protein. | 0.673 |
ABI64298.1 | dut | Mmar10_0002 | Mmar10_3068 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.834 |
ABI64298.1 | thyA | Mmar10_0002 | Mmar10_2027 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.769 |
ABI64598.1 | ABI64785.1 | Mmar10_0305 | Mmar10_0492 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: tbd:Tbd_2171 ribonucleotide reductase. | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: nwi:Nwi_0140 2'-deoxycytidine 5'-triphosphate deaminase. | 0.905 |
ABI64598.1 | dut | Mmar10_0305 | Mmar10_3068 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: tbd:Tbd_2171 ribonucleotide reductase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.923 |
ABI64598.1 | ndk | Mmar10_0305 | Mmar10_1234 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: tbd:Tbd_2171 ribonucleotide reductase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.913 |
ABI64692.1 | ABI64298.1 | Mmar10_0399 | Mmar10_0002 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.673 |
ABI64692.1 | ABI65553.1 | Mmar10_0399 | Mmar10_1261 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | KEGG: ccr:CC1889 ribonucleotide reductase-related protein. | 0.904 |
ABI64692.1 | dut | Mmar10_0399 | Mmar10_3068 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.652 |
ABI64692.1 | ndk | Mmar10_0399 | Mmar10_1234 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.912 |
ABI64692.1 | thyA | Mmar10_0399 | Mmar10_2027 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.686 |
ABI64692.1 | tmk | Mmar10_0399 | Mmar10_1454 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
ABI64785.1 | ABI64598.1 | Mmar10_0492 | Mmar10_0305 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: nwi:Nwi_0140 2'-deoxycytidine 5'-triphosphate deaminase. | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: tbd:Tbd_2171 ribonucleotide reductase. | 0.905 |
ABI64785.1 | dut | Mmar10_0492 | Mmar10_3068 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: nwi:Nwi_0140 2'-deoxycytidine 5'-triphosphate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.926 |
ABI64785.1 | ndk | Mmar10_0492 | Mmar10_1234 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: nwi:Nwi_0140 2'-deoxycytidine 5'-triphosphate deaminase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.925 |
ABI64785.1 | tmk | Mmar10_0492 | Mmar10_1454 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: nwi:Nwi_0140 2'-deoxycytidine 5'-triphosphate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.457 |
ABI65553.1 | ABI64298.1 | Mmar10_1261 | Mmar10_0002 | KEGG: ccr:CC1889 ribonucleotide reductase-related protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.673 |
ABI65553.1 | ABI64692.1 | Mmar10_1261 | Mmar10_0399 | KEGG: ccr:CC1889 ribonucleotide reductase-related protein. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.904 |
ABI65553.1 | dut | Mmar10_1261 | Mmar10_3068 | KEGG: ccr:CC1889 ribonucleotide reductase-related protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.724 |