node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccel_0327 | Ccel_0492 | Ccel_0327 | Ccel_0492 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | 0.773 |
Ccel_0327 | Ccel_0585 | Ccel_0327 | Ccel_0585 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | KEGG: fma:FMG_1340 hypothetical protein. | 0.709 |
Ccel_0327 | Ccel_1465 | Ccel_0327 | Ccel_1465 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; KEGG: cno:NT01CX_1376 molecular chaperone. | 0.783 |
Ccel_0327 | dnaJ | Ccel_0327 | Ccel_1797 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.783 |
Ccel_0327 | dnaK | Ccel_0327 | Ccel_1798 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.959 |
Ccel_0327 | groL | Ccel_0327 | Ccel_0392 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.717 |
Ccel_0327 | groS | Ccel_0327 | Ccel_0391 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.738 |
Ccel_0327 | grpE | Ccel_0327 | Ccel_1799 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.874 |
Ccel_0327 | hrcA | Ccel_0327 | Ccel_1800 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.674 |
Ccel_0492 | Ccel_0327 | Ccel_0492 | Ccel_0327 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.773 |
Ccel_0492 | Ccel_0585 | Ccel_0492 | Ccel_0585 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | KEGG: fma:FMG_1340 hypothetical protein. | 0.864 |
Ccel_0492 | Ccel_1465 | Ccel_0492 | Ccel_1465 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | PFAM: heat shock protein DnaJ domain protein; KEGG: cno:NT01CX_1376 molecular chaperone. | 0.901 |
Ccel_0492 | Ccel_2116 | Ccel_0492 | Ccel_2116 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.773 |
Ccel_0492 | dnaJ | Ccel_0492 | Ccel_1797 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.901 |
Ccel_0492 | dnaK | Ccel_0492 | Ccel_1798 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
Ccel_0492 | groL | Ccel_0492 | Ccel_0392 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.941 |
Ccel_0492 | groS | Ccel_0492 | Ccel_0391 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.895 |
Ccel_0492 | grpE | Ccel_0492 | Ccel_1799 | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.880 |
Ccel_0585 | Ccel_0327 | Ccel_0585 | Ccel_0327 | KEGG: fma:FMG_1340 hypothetical protein. | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.709 |
Ccel_0585 | Ccel_0492 | Ccel_0585 | Ccel_0492 | KEGG: fma:FMG_1340 hypothetical protein. | PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. | 0.864 |