STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (432 aa)    
Predicted Functional Partners:
hemL
COG0001: Glutamate-1-semialdehyde aminotransferase, Ralstonia solanacearum; KEGG, K01845.
 
 0.997
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.988
hemL-2
COG0001: Glutamate-1-semialdehyde aminotransferase, Pseudomonas aeruginosa; KEGG, K01845; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.982
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.968
hemB
Porphobilinogen synthase; COG0113: Delta-aminolevulinic acid dehydratase, Ralstonia solanacearum; KEGG, K01698; Belongs to the ALAD family.
 
  
 0.875
gltX-2
glutamyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
  
  
 0.811
cysG-3
uroporphyrin-III C-methyltransferase; COG0007: Uroporphyrinogen-III methylase, Pseudomonas aeruginosa; KEGG, K02302.
 
  
 0.755
cysG
uroporphyrin-III C-methyltransferase; COG0007: Uroporphyrinogen-III methylase, Pseudomonas aeruginosa; KEGG, K02302.
 
  
 0.753
prfA
Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.747
cysG-2
uroporphyrin-III C-methyltransferase; COG0007: Uroporphyrinogen-III methylase, Ralstonia solanacearum; KEGG, K02302; Belongs to the precorrin methyltransferase family.
 
  
 0.742
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.