STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (444 aa)    
Predicted Functional Partners:
hppD
COG3185: 4-hydroxyphenylpyruvate dioxygenase and related hemolysins, Ralstonia solanacearum; KEGG, K00457.
 
 0.998
hppD-2
COG3185: 4-hydroxyphenylpyruvate dioxygenase and related hemolysins, Ralstonia solanacearum; KEGG, K00457.
 
 0.998
fah
Fumarylacetoacetase; COG0179: 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway), Ralstonia solanacearum; KEGG, K01555.
 
  
 0.997
hppD-3
COG3185: 4-hydroxyphenylpyruvate dioxygenase and related hemolysins, Pseudomonas aeruginosa; KEGG, K00457.
 
 0.997
maiA
Maleylacetoacetate isomerase; COG0625: Glutathione S-transferase, Ralstonia solanacearum; KEGG, K01800.
 
 
 0.968
maiA-3
Maleylacetoacetate isomerase; COG0625: Glutathione S-transferase, Ralstonia solanacearum; KEGG, K01800.
 
 
 0.965
pah
COG3186: Phenylalanine-4-hydroxylase, Ralstonia solanacearum; KEGG, K00500.
 
  
 0.954
BAG43248.1
Conserved hypothetical protein.
  
 0.885
BAG42636.1
Conserved hypothetical protein.
 
     0.871
mhpA
COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases, Ralstonia solanacearum; KEGG, K05712.
 
  
 0.858
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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