node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG42177.1 | fmt | BMULJ_00202 | BMULJ_00107 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.577 |
BAG42177.1 | fmt-2 | BMULJ_00202 | BMULJ_01831 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | 0.577 |
BAG42177.1 | folD | BMULJ_00202 | BMULJ_02124 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
BAG42177.1 | glyA | BMULJ_00202 | BMULJ_00657 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.461 |
BAG42177.1 | glyA-2 | BMULJ_00202 | BMULJ_04971 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.469 |
BAG42177.1 | purH | BMULJ_00202 | BMULJ_00545 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful), Ralstonia solanacearum; KEGG, K00602. | 0.636 |
fmt | BAG42177.1 | BMULJ_00107 | BMULJ_00202 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | 0.577 |
fmt | fmt-2 | BMULJ_00107 | BMULJ_01831 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | 0.912 |
fmt | folD | BMULJ_00107 | BMULJ_02124 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.970 |
fmt | gcvT | BMULJ_00107 | BMULJ_03122 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
fmt | glyA | BMULJ_00107 | BMULJ_00657 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.922 |
fmt | glyA-2 | BMULJ_00107 | BMULJ_04971 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
fmt | metF | BMULJ_00107 | BMULJ_03082 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | COG0685: 5,10-methylenetetrahydrofolate reductase, Ralstonia solanacearum; KEGG, K00297. | 0.576 |
fmt | purH | BMULJ_00107 | BMULJ_00545 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful), Ralstonia solanacearum; KEGG, K00602. | 0.575 |
fmt | thyA | BMULJ_00107 | BMULJ_01021 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.742 |
fmt-2 | BAG42177.1 | BMULJ_01831 | BMULJ_00202 | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. | 0.577 |
fmt-2 | fmt | BMULJ_01831 | BMULJ_00107 | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
fmt-2 | folD | BMULJ_01831 | BMULJ_02124 | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.983 |
fmt-2 | gcvT | BMULJ_01831 | BMULJ_03122 | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
fmt-2 | glyA | BMULJ_01831 | BMULJ_00657 | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |