node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | BMULJ_01960 | BMULJ_02921 | Glutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | 0.967 |
guaA | hisB | BMULJ_01960 | BMULJ_02924 | Glutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | 0.500 |
guaA | hisF | BMULJ_01960 | BMULJ_02920 | Glutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.629 |
guaA | hisH | BMULJ_01960 | BMULJ_02922 | Glutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.637 |
hisA | guaA | BMULJ_02921 | BMULJ_01960 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | Glutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.967 |
hisA | hisB | BMULJ_02921 | BMULJ_02924 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | 0.997 |
hisA | hisC-2 | BMULJ_02921 | BMULJ_02925 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase, Ralstonia solanacearum; KEGG, K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.961 |
hisA | hisD | BMULJ_02921 | BMULJ_02926 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisE | BMULJ_02921 | BMULJ_02918 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | COG0140: Phosphoribosyl-ATP pyrophosphohydrolase, Ralstonia solanacearum; KEGG, K01523. | 0.998 |
hisA | hisF | BMULJ_02921 | BMULJ_02920 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | BMULJ_02921 | BMULJ_02927 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.997 |
hisA | hisH | BMULJ_02921 | BMULJ_02922 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BMULJ_02921 | BMULJ_02919 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | BMULJ_02921 | BMULJ_01770 | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.976 |
hisB | guaA | BMULJ_02924 | BMULJ_01960 | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | Glutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.500 |
hisB | hisA | BMULJ_02924 | BMULJ_02921 | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase, Ralstonia solanacearum; KEGG, K01814. | 0.997 |
hisB | hisC-2 | BMULJ_02924 | BMULJ_02925 | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase, Ralstonia solanacearum; KEGG, K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | BMULJ_02924 | BMULJ_02926 | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | BMULJ_02924 | BMULJ_02918 | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | COG0140: Phosphoribosyl-ATP pyrophosphohydrolase, Ralstonia solanacearum; KEGG, K01523. | 0.997 |
hisB | hisF | BMULJ_02924 | BMULJ_02920 | COG0131: Imidazoleglycerol-phosphate dehydratase, Ralstonia solanacearum; KEGG, K01693. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |