node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG46562.1 | gcvH | BMULJ_04715 | BMULJ_03123 | Conserved hypothetical protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.421 |
BAG46562.1 | gcvP | BMULJ_04715 | BMULJ_03124 | Conserved hypothetical protein. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.979 |
BAG46562.1 | gcvT | BMULJ_04715 | BMULJ_03122 | Conserved hypothetical protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.509 |
BAG46562.1 | gltS | BMULJ_04715 | BMULJ_02949 | Conserved hypothetical protein. | COG0069: Glutamate synthase domain 2, Ralstonia solanacearum; KEGG, K00284. | 0.445 |
BAG46562.1 | glyA | BMULJ_04715 | BMULJ_00657 | Conserved hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.787 |
BAG46562.1 | glyA-2 | BMULJ_04715 | BMULJ_04971 | Conserved hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.787 |
BAG46562.1 | purL | BMULJ_04715 | BMULJ_01883 | Conserved hypothetical protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.997 |
BAG46562.1 | soxA-2 | BMULJ_04715 | BMULJ_05011 | Conserved hypothetical protein. | Sarcosine oxidase alpha subunit; COG0446: Uncharacterized NAD(FAD)-dependent dehydrogenases, Ralstonia solanacearum; KEGG, K00302; Belongs to the GcvT family. | 0.517 |
gcvH | BAG46562.1 | BMULJ_03123 | BMULJ_04715 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Conserved hypothetical protein. | 0.421 |
gcvH | gcvP | BMULJ_03123 | BMULJ_03124 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | BMULJ_03123 | BMULJ_03122 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | gltS | BMULJ_03123 | BMULJ_02949 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | COG0069: Glutamate synthase domain 2, Ralstonia solanacearum; KEGG, K00284. | 0.935 |
gcvH | glyA | BMULJ_03123 | BMULJ_00657 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
gcvH | glyA-2 | BMULJ_03123 | BMULJ_04971 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
gcvH | pdhD-2 | BMULJ_03123 | BMULJ_02119 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00382. | 0.994 |
gcvH | purD | BMULJ_03123 | BMULJ_02281 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | COG0151: Phosphoribosylamine-glycine ligase, Ralstonia solanacearum; KEGG, K01945; Belongs to the GARS family. | 0.421 |
gcvH | purL | BMULJ_03123 | BMULJ_01883 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.790 |
gcvH | soxA-2 | BMULJ_03123 | BMULJ_05011 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Sarcosine oxidase alpha subunit; COG0446: Uncharacterized NAD(FAD)-dependent dehydrogenases, Ralstonia solanacearum; KEGG, K00302; Belongs to the GcvT family. | 0.999 |
gcvP | BAG46562.1 | BMULJ_03124 | BMULJ_04715 | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Conserved hypothetical protein. | 0.979 |
gcvP | gcvH | BMULJ_03124 | BMULJ_03123 | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |