node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bioB | queE | BMULJ_02883 | BMULJ_00116 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.577 |
bioB | tpiA | BMULJ_02883 | BMULJ_02238 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.425 |
exsB | ptpS | BMULJ_00115 | BMULJ_00117 | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | COG0720: 6-pyruvoyl-tetrahydropterin synthase, Ralstonia solanacearum; KEGG, K01737. | 0.987 |
exsB | queE | BMULJ_00115 | BMULJ_00116 | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.999 |
exsB | ykvM | BMULJ_00115 | BMULJ_02700 | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.986 |
folE | folE-2 | BMULJ_03230 | BMULJ_05688 | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | 0.494 |
folE | nrdA | BMULJ_03230 | BMULJ_00448 | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.759 |
folE | ptpS | BMULJ_03230 | BMULJ_00117 | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | COG0720: 6-pyruvoyl-tetrahydropterin synthase, Ralstonia solanacearum; KEGG, K01737. | 0.983 |
folE | queE | BMULJ_03230 | BMULJ_00116 | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.600 |
folE | ykvM | BMULJ_03230 | BMULJ_02700 | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.532 |
folE-2 | folE | BMULJ_05688 | BMULJ_03230 | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | 0.494 |
folE-2 | nrdA | BMULJ_05688 | BMULJ_00448 | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.759 |
folE-2 | ptpS | BMULJ_05688 | BMULJ_00117 | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | COG0720: 6-pyruvoyl-tetrahydropterin synthase, Ralstonia solanacearum; KEGG, K01737. | 0.948 |
folE-2 | queE | BMULJ_05688 | BMULJ_00116 | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.600 |
folE-2 | ykvM | BMULJ_05688 | BMULJ_02700 | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.532 |
nrdA | folE | BMULJ_00448 | BMULJ_03230 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | 0.759 |
nrdA | folE-2 | BMULJ_00448 | BMULJ_05688 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | COG0302: GTP cyclohydrolase I, Mycobacterium leprae; KEGG, K01495. | 0.759 |
nrdA | queE | BMULJ_00448 | BMULJ_00116 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.982 |
ptpS | exsB | BMULJ_00117 | BMULJ_00115 | COG0720: 6-pyruvoyl-tetrahydropterin synthase, Ralstonia solanacearum; KEGG, K01737. | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.987 |
ptpS | folE | BMULJ_00117 | BMULJ_03230 | COG0720: 6-pyruvoyl-tetrahydropterin synthase, Ralstonia solanacearum; KEGG, K01737. | COG0302: GTP cyclohydrolase I, Xylella fastidiosa 9a5c; KEGG, K01495. | 0.983 |