node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACI55174.1 | ACI55815.1 | Rleg2_1889 | Rleg2_2542 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.904 |
ACI55174.1 | ACI55889.1 | Rleg2_1889 | Rleg2_2618 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | KEGG: rec:RHECIAT_CH0003023 5,10-methylenetetrahydrofolate reductase protein; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.918 |
ACI55174.1 | ACI55922.1 | Rleg2_1889 | Rleg2_2651 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
ACI55174.1 | fhs | Rleg2_1889 | Rleg2_2815 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.926 |
ACI55174.1 | folD | Rleg2_1889 | Rleg2_0353 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
ACI55174.1 | folD-2 | Rleg2_1889 | Rleg2_1627 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
ACI55174.1 | glyA | Rleg2_1889 | Rleg2_1177 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.989 |
ACI55174.1 | glyA-2 | Rleg2_1889 | Rleg2_1626 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
ACI55174.1 | purH | Rleg2_1889 | Rleg2_3915 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | KEGG: rec:RHECIAT_CH0004399 IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.929 |
ACI55174.1 | purN | Rleg2_1889 | Rleg2_1094 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.922 |
ACI55815.1 | ACI55174.1 | Rleg2_2542 | Rleg2_1889 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | 0.904 |
ACI55815.1 | ACI55922.1 | Rleg2_2542 | Rleg2_2651 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.913 |
ACI55815.1 | fhs | Rleg2_2542 | Rleg2_2815 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.915 |
ACI55815.1 | glyA | Rleg2_2542 | Rleg2_1177 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
ACI55815.1 | glyA-2 | Rleg2_2542 | Rleg2_1626 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
ACI55815.1 | purH | Rleg2_2542 | Rleg2_3915 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: rec:RHECIAT_CH0004399 IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.913 |
ACI55815.1 | purN | Rleg2_2542 | Rleg2_1094 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.910 |
ACI55889.1 | ACI55174.1 | Rleg2_2618 | Rleg2_1889 | KEGG: rec:RHECIAT_CH0003023 5,10-methylenetetrahydrofolate reductase protein; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rec:RHECIAT_CH0002350 aminomethyltransferase protein. | 0.918 |
ACI55889.1 | ACI55922.1 | Rleg2_2618 | Rleg2_2651 | KEGG: rec:RHECIAT_CH0003023 5,10-methylenetetrahydrofolate reductase protein; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
ACI55889.1 | fhs | Rleg2_2618 | Rleg2_2815 | KEGG: rec:RHECIAT_CH0003023 5,10-methylenetetrahydrofolate reductase protein; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.794 |