STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXPFAM: peptidase M48 Ste24p; KEGG: rec:RHECIAT_CH0004402 protease protein, heat-shock protein-like protein; Belongs to the peptidase M48B family. (320 aa)    
Predicted Functional Partners:
ACI57179.1
PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: rec:RHECIAT_CH0004401 probable RNA methyltransferase-sun protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
       0.800
ACI57037.1
TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: ret:RHE_CH03979 thioredoxin protein.
  
  
 0.602
grpE
Ribulose-phosphate 3-epimerase; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
  
  
 0.600
ACI57181.1
PFAM: protein of unknown function DUF1674; KEGG: ret:RHE_CH04111 hypothetical protein.
       0.595
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.571
ACI56663.1
PFAM: protein of unknown function DUF533; KEGG: rec:RHECIAT_CH0003905 hypothetical protein.
   
    0.522
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.521
ACI57178.1
PFAM: Heparinase II/III family protein; KEGG: rec:RHECIAT_CH0004400 hypothetical protein.
       0.505
lon
ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
   
 
 0.495
ACI54862.1
KEGG: rec:RHECIAT_CH0002000 ATP-dependent Clp protease protein, ATP-binding subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.
  
  
 0.470
Your Current Organism:
Rhizobium leguminosarum
NCBI taxonomy Id: 395492
Other names: R. leguminosarum bv. trifolii WSM2304, Rhizobium leguminosarum bv. trifolii WSM2304, Rhizobium leguminosarum bv. trifolii str. WSM2304, Rhizobium leguminosarum bv. trifolii strain WSM2304
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.