node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msil_0137 | Msil_1478 | Msil_0137 | Msil_1478 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.979 |
Msil_0137 | Msil_2987 | Msil_0137 | Msil_2987 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: pzu:PHZ_p0134 pyruvate:ferredoxin oxidoreductase. | 0.958 |
Msil_0137 | Msil_2996 | Msil_0137 | Msil_2996 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: rec:RHECIAT_CH0004306 acetyl-CoA acetyltransferase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.923 |
Msil_0137 | Msil_3619 | Msil_0137 | Msil_3619 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: pyruvate carboxyltransferase; KEGG: rpa:RPA4607 putative homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.925 |
Msil_0137 | acsA | Msil_0137 | Msil_1226 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.922 |
Msil_0137 | leuA | Msil_0137 | Msil_0683 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.922 |
Msil_1477 | Msil_1478 | Msil_1477 | Msil_1478 | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ppf:Pput_2875 4-oxalocrotonate decarboxylase. | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.978 |
Msil_1477 | Msil_1479 | Msil_1477 | Msil_1479 | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ppf:Pput_2875 4-oxalocrotonate decarboxylase. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.995 |
Msil_1477 | Msil_1480 | Msil_1477 | Msil_1480 | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ppf:Pput_2875 4-oxalocrotonate decarboxylase. | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: nar:Saro_3851 hydratase/decarboxylase. | 0.980 |
Msil_1478 | Msil_0137 | Msil_1478 | Msil_0137 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bid:Bind_1913 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.979 |
Msil_1478 | Msil_1477 | Msil_1478 | Msil_1477 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ppf:Pput_2875 4-oxalocrotonate decarboxylase. | 0.978 |
Msil_1478 | Msil_1479 | Msil_1478 | Msil_1479 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.998 |
Msil_1478 | Msil_1480 | Msil_1478 | Msil_1480 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: nar:Saro_3851 hydratase/decarboxylase. | 0.978 |
Msil_1478 | Msil_1743 | Msil_1478 | Msil_1743 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | KEGG: bid:Bind_1756 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.910 |
Msil_1478 | Msil_2987 | Msil_1478 | Msil_2987 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: pzu:PHZ_p0134 pyruvate:ferredoxin oxidoreductase. | 0.911 |
Msil_1478 | Msil_2996 | Msil_1478 | Msil_2996 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | KEGG: rec:RHECIAT_CH0004306 acetyl-CoA acetyltransferase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.910 |
Msil_1478 | Msil_3619 | Msil_1478 | Msil_3619 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | PFAM: pyruvate carboxyltransferase; KEGG: rpa:RPA4607 putative homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.979 |
Msil_1478 | acsA | Msil_1478 | Msil_1226 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.910 |
Msil_1478 | leuA | Msil_1478 | Msil_0683 | Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.979 |
Msil_1479 | Msil_1477 | Msil_1479 | Msil_1477 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ppf:Pput_2875 4-oxalocrotonate decarboxylase. | 0.995 |