node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tgr7_1838 | Tgr7_2956 | Tgr7_1838 | Tgr7_2956 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | 0.720 |
Tgr7_1838 | dnaJ | Tgr7_1838 | Tgr7_0973 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.713 |
Tgr7_1838 | dnaK | Tgr7_1838 | Tgr7_0972 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.903 |
Tgr7_1838 | groL | Tgr7_1838 | Tgr7_0439 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.643 |
Tgr7_1838 | groS | Tgr7_1838 | Tgr7_0438 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.663 |
Tgr7_1838 | grpE | Tgr7_1838 | Tgr7_0971 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.856 |
Tgr7_1838 | hrcA | Tgr7_1838 | Tgr7_0970 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.594 |
Tgr7_1838 | htpG | Tgr7_1838 | Tgr7_0860 | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.721 |
Tgr7_2956 | Tgr7_1838 | Tgr7_2956 | Tgr7_1838 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | 0.720 |
Tgr7_2956 | clpB | Tgr7_2956 | Tgr7_0817 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.720 |
Tgr7_2956 | dnaK | Tgr7_2956 | Tgr7_0972 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.979 |
Tgr7_2956 | groL | Tgr7_2956 | Tgr7_0439 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.808 |
Tgr7_2956 | groS | Tgr7_2956 | Tgr7_0438 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.733 |
Tgr7_2956 | grpE | Tgr7_2956 | Tgr7_0971 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.950 |
Tgr7_2956 | hrcA | Tgr7_2956 | Tgr7_0970 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.722 |
Tgr7_2956 | htpG | Tgr7_2956 | Tgr7_0860 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.967 |
Tgr7_2956 | rplP | Tgr7_2956 | Tgr7_2317 | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.662 |
clpB | Tgr7_2956 | Tgr7_0817 | Tgr7_2956 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | KEGG: aeh:Mlg_2130 heat shock protein DnaJ domain-containing protein. | 0.720 |
clpB | dnaJ | Tgr7_0817 | Tgr7_0973 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.713 |
clpB | dnaK | Tgr7_0817 | Tgr7_0972 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.903 |