node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tgr7_0341 | Tgr7_2961 | Tgr7_0341 | Tgr7_2961 | TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: tbd:Tbd_1651 hypothetical protein. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.855 |
Tgr7_1752 | Tgr7_2431 | Tgr7_1752 | Tgr7_2431 | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | 0.914 |
Tgr7_1752 | Tgr7_2930 | Tgr7_1752 | Tgr7_2930 | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | KEGG: pau:PA14_68390 putative hydrolase. | 0.900 |
Tgr7_1752 | Tgr7_2961 | Tgr7_1752 | Tgr7_2961 | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.905 |
Tgr7_1752 | guaA | Tgr7_1752 | Tgr7_1036 | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.957 |
Tgr7_1752 | guaB | Tgr7_1752 | Tgr7_1035 | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
Tgr7_1752 | surE | Tgr7_1752 | Tgr7_1432 | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Tgr7_2431 | Tgr7_1752 | Tgr7_2431 | Tgr7_1752 | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | 0.914 |
Tgr7_2431 | Tgr7_2930 | Tgr7_2431 | Tgr7_2930 | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | KEGG: pau:PA14_68390 putative hydrolase. | 0.902 |
Tgr7_2431 | Tgr7_2961 | Tgr7_2431 | Tgr7_2961 | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
Tgr7_2431 | guaA | Tgr7_2431 | Tgr7_1036 | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.910 |
Tgr7_2431 | guaB | Tgr7_2431 | Tgr7_1035 | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.925 |
Tgr7_2431 | surE | Tgr7_2431 | Tgr7_1432 | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.910 |
Tgr7_2930 | Tgr7_1752 | Tgr7_2930 | Tgr7_1752 | KEGG: pau:PA14_68390 putative hydrolase. | KEGG: csa:Csal_2065 hypoxanthine-guanine phosphoribosyltransferase. | 0.900 |
Tgr7_2930 | Tgr7_2431 | Tgr7_2930 | Tgr7_2431 | KEGG: pau:PA14_68390 putative hydrolase. | KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. | 0.902 |
Tgr7_2930 | Tgr7_2961 | Tgr7_2930 | Tgr7_2961 | KEGG: pau:PA14_68390 putative hydrolase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
Tgr7_2930 | guaA | Tgr7_2930 | Tgr7_1036 | KEGG: pau:PA14_68390 putative hydrolase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.916 |
Tgr7_2930 | guaB | Tgr7_2930 | Tgr7_1035 | KEGG: pau:PA14_68390 putative hydrolase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.931 |
Tgr7_2930 | surE | Tgr7_2930 | Tgr7_1432 | KEGG: pau:PA14_68390 putative hydrolase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
Tgr7_2961 | Tgr7_0341 | Tgr7_2961 | Tgr7_0341 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: tbd:Tbd_1651 hypothetical protein. | 0.855 |