node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aave_1171 | Aave_1172 | Aave_1171 | Aave_1172 | PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit; KEGG: pol:Bpro_3712 procollagen-proline, 2-oxoglutarate-4-dioxygenase. | PFAM: protein of unknown function DUF328; KEGG: rfr:Rfer_2372 protein of unknown function DUF328; Belongs to the UPF0246 family. | 0.621 |
Aave_1171 | queF | Aave_1171 | Aave_1170 | PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit; KEGG: pol:Bpro_3712 procollagen-proline, 2-oxoglutarate-4-dioxygenase. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.733 |
Aave_1171 | rne | Aave_1171 | Aave_1173 | PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit; KEGG: pol:Bpro_3712 procollagen-proline, 2-oxoglutarate-4-dioxygenase. | RNAse E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 0.419 |
Aave_1172 | Aave_1171 | Aave_1172 | Aave_1171 | PFAM: protein of unknown function DUF328; KEGG: rfr:Rfer_2372 protein of unknown function DUF328; Belongs to the UPF0246 family. | PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit; KEGG: pol:Bpro_3712 procollagen-proline, 2-oxoglutarate-4-dioxygenase. | 0.621 |
Aave_1172 | queF | Aave_1172 | Aave_1170 | PFAM: protein of unknown function DUF328; KEGG: rfr:Rfer_2372 protein of unknown function DUF328; Belongs to the UPF0246 family. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.692 |
Aave_1172 | rne | Aave_1172 | Aave_1173 | PFAM: protein of unknown function DUF328; KEGG: rfr:Rfer_2372 protein of unknown function DUF328; Belongs to the UPF0246 family. | RNAse E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 0.561 |
Aave_2270 | guaA | Aave_2270 | Aave_3367 | GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.688 |
Aave_2270 | queF | Aave_2270 | Aave_1170 | GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.753 |
Aave_3845 | guaA | Aave_3845 | Aave_3367 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: pol:Bpro_1495 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.484 |
Aave_3845 | queC | Aave_3845 | Aave_0139 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: pol:Bpro_1495 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.951 |
Aave_3845 | queE | Aave_3845 | Aave_3844 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: pol:Bpro_1495 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.998 |
Aave_3845 | queF | Aave_3845 | Aave_1170 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: pol:Bpro_1495 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.865 |
guaA | Aave_2270 | Aave_3367 | Aave_2270 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | 0.688 |
guaA | Aave_3845 | Aave_3367 | Aave_3845 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: pol:Bpro_1495 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | 0.484 |
guaA | queE | Aave_3367 | Aave_3844 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.552 |
guaA | queF | Aave_3367 | Aave_1170 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.593 |
guaA | ribB | Aave_3367 | Aave_2232 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.686 |
guaA | tgt | Aave_3367 | Aave_4479 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.661 |
queC | Aave_3845 | Aave_0139 | Aave_3845 | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: pol:Bpro_1495 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | 0.951 |
queC | queE | Aave_0139 | Aave_3844 | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.994 |